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The Cancer Microbiome Atlas gives clearer picture of microbiota living in organs

The Cancer Microbiome Atlas gives clearer picture of microbiota living in organs
Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in various organs in both healthy and cancerous states, researchers will now be able to find new biomarkers of disease and better understand how numerous cancers affect the human body.
In the first study using the newly decontaminated dataset, the researchers have already discovered that normal and cancerous organ tissues have a slightly different microbiota composition, that bacteria from these diseased sites can enter the bloodstream, and that this bacterial information could help diagnose cancer and predict patient outcomes. ....

Xiling Shen , Anders Dohlman , Microbiome Atlas , Emily Henderson , Duke University , Cancer Genome Atlas , Cell Host , Hawkins Family Associate Professor , Biomedical Engineering , Cancer Microbiome Atlas , Colorectal Cancer , Genetic Information , எமிலி ஹென்டர்சன் , டியூக் பல்கலைக்கழகம் , புற்றுநோய் மரபணு அட்லஸ் , செல் தொகுப்பாளர் , ஹாக்கின்ஸ் குடும்பம் இணை ப்ரொஃபெஸர் , உயிர் மருத்துவ பொறியியல் , பெருங்குடல் புற்றுநோய் , ஜெநெடிக் தகவல் ,

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

As the COVID-19 pandemic continues to infect people in their hundreds of thousands around the world, a new study describes a panel of novel tests for genomic (g) and subgenomic (sg) mRNAs generated by SARS-CoV-2. Most assays in use at present are either qualitative or semi-quantitative, and cannot evaluate the transcription molecules in detail. ....

Liji Thomas , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Gene Expression , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கொரோனா வைரஸ் , கீந் வெளிப்பாடு , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?
The unchecked advance of the coronavirus disease 2019 (COVID-19) has made it a top public health priority to produce a vaccine capable of inducing a safe and powerful protective response against its causative pathogen: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An encouraging new preprint, that appeared on the
bioRxiv server shows the immunogenicity, safety, and protective efficacy, of a Newcastle disease virus (NDV)-based intranasal vector vaccine in animal studies.
A host of candidate vaccines being developed against SARS-CoV-2 use viral vector platforms to present the SARS-CoV-2 spike antigen to the host immune system. Many have used the intramuscular route (i.e., ‘jabs’ or ‘shots’), but the intranasal route allows the development of local or mucosal immunity as well as systemic immunity against the virus. This will allow protection against not just s ....

Liji Thomas , Josep Suria Shutterstock , Drug Administration , Protective Efficacy , Intranasal Live Attenuated Vaccine Against , Preclinical Animal , Image Credit , Josep Suria , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Immune System , Public Health , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Viral Vector , படம் கடன் , ஜோசப் சூரியா , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி அமைப்பு , பொது ஆரோக்கியம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , வைரஸ் திசையன் ,

Daily circadian cycles may impact our ability to fight disease

Daily circadian cycles may impact our ability to fight disease
An analysis of an exhaustive dataset on cells essential to the mammalian immune system shows that our ability to fight disease may rely more heavily on daily circadian cycles than previously assumed.
Malfunctions in circadian rhythms, the process that keeps our bodies in tune with the day/night cycles, are increasingly associated with diabetes, cancer, Alzheimer s, and many other diseases. An investigation published today in
Genome Research shows that the activity of macrophages -; cells within us that seek and destroy intruders like bacteria -; may time daily changes in their responses to pathogens and stress through the circadian control of metabolism. ....

Jennifer Hurley , Nannie Curtis , Emily Henderson , Genome Research , Royal College Of Surgeons , Development Assistant Professor , Biological Sciences , Rensselaer Polytechnic Institute , Cell Systems , Rensselaer Polytechnic , Royal College , Immune System , ஜெனிபர் ஹர்லி , அன்னயே கர்டிஸ் , எமிலி ஹென்டர்சன் , மரபணு ஆராய்ச்சி , அரச கல்லூரி ஆஃப் அறுவை சிகிச்சை நிபுணர்கள் , வளர்ச்சி உதவியாளர் ப்ரொஃபெஸர் , உயிரியல் அறிவியல் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , செல் அமைப்புகள் , ரென்சீலர் பாலிடெக்நிக் , அரச கல்லூரி , நோய் எதிர்ப்பு சக்தி அமைப்பு , நீரிழிவு நோய் , வளர்சிதை மாற்றம் ,

Large study provides new understanding of genome diversity in Ukrainian population

Today, the largest study of genetic diversity in Ukraine was published in the open science journal GigaScience. ....

Zakarpats Ka Oblast , Taras Oleksyk , Emily Henderson , Oakland University , Genomic Research , Uzhhorod National University , Central Europe Center , Human Genome Diversity Project , Middle Ages , Lead Investigator , Leber Congenital Amaurosis , Breast Cancer , எமிலி ஹென்டர்சன் , ஓக்லாண்ட் பல்கலைக்கழகம் , மைய யூரோப் மையம் , மனிதன் மரபணு பன்முகத்தன்மை ப்ராஜெக்ட் , வழி நடத்து புலனாய்வாளர் , மன இறுக்கம் , மார்பக புற்றுநோய் ,