Unearthing individual-level mutation risk patterns
Mutations, which occur continuously in every cell of our bodies, are a key contributor to cancer, ageing, and neurodegeneration.
Source: news-medical.net
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Unravelling individual differences in DNA mutation risks
Researchers at IRB Barcelona discover unexpected patterns in mutation risks across individuals, uncovering 13 distinct genomic patterns.
Source: newswise.com
Gift from Schmidt Futures to spark a revolution in AI-based STEM research at the University of Toronto
With the goal of accelerating scientific research through the application of artificial intelligence, Schmidt Futures is investing $148-million in nine global universities, including the University of Toronto.
Source: utoronto.ca
IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response
CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.
Source: news-medical.net
Gene editing via CRISPR/Cas9 can lead to cell toxicity and genome instability
Gene editing via CRISPR/Cas9 can lead to cell toxicity and genome instability
Source: biotech-spain.com