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IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions. ....

Comunidad Autonoma De Cataluna , Fran Supek , Emmanuelle Charpentier , Jennifera Doudna , Emily Henderson , Nature Communications , Institute For Research , Genome Data Science , Dna Damage ,

Study: CRISPR gene editing can lead to cell toxicity and genome instability

Scientists at IRB Barcelona say CRISPR gene editing can give rise to cell toxicity and genomic instability.  ....

Comunidad Autonoma De Cataluna , Fran Supek , Nature Communications , Genome Data Science ,

Not individual genes but "mutational signatures" of many genes hold key to better cancer therapies

Not individual genes but "mutational signatures" of many genes hold key to better cancer therapies
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Comunidad Autonoma De Cataluna , Jurica Levati , Marie Curie , Marina Salvadores , Fran Supek , Spanish Ministry Of Science , Jozef Stefan Institute , Genome Data Science , Spanish Ministry ,