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Researchers uncover the role of inherited genetic variants in rare type of blood cancer

Large-scale genetic analysis has helped researchers uncover the interplay between cancer-driving genetic mutations and inherited genetic variants in a rare type of blood cancer. ....

United Kingdom , Nicole Soranzo , Jyoti Nangalia , Jing Guo , University Of Cambridge , Cambridge Stem Cell Institute , Wellcome Trust Sanger Institute , Wellcome Sanger Institute , Trust Sanger , Nature Genetics , Human Technopole , Stem Cell Institute , Blood Cancer , Bone Marrow ,

Next-gen genomics reveals diversity of Indigenous Australians

Researchers identified more than 160,000 structural genetic variants, which is more than any previous population-level long-read study to date. ....

Northern Territory , Hardip Patel , Ira Deveson , Oxford Nanopore , Gimuy Walubara Yidinji , Garvan Institute Of Medical Research , Genomic Technologies Lab At Garvan , National Centre For Indigenous Genomics , Indigenous Australians , Indigenous Genomics , Garvan Institute , Medical Research , Genomic Technologies Lab , Torres Strait Islander , Professor Azure Hermes , Deputy Director , Machado Joseph Disease , Genetic Diversity , Indigenous Australians , Garvan Institute Of Medical Research , Nu National Centre For Indigenous Genomics ,

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care

Researchers evaluated the impact of integrating whole-genome sequencing data with clinical outcomes across 13,880 tumors from 33 cancer types, assessing precision care potentials within the UK NHS through the 100,000 Genomes Cancer Programme. ....

United Kingdom , Sequencin Hiseq , Cancer Programme , National Genomic Test Directory , Cambridge South Research Ethics Committee , Research Environment , National Cancer Registration , Analysis Service , Genomic Medicine Service , Genomes Cancer Programme , Public Health England , Office For National Statistics , National Genomic Research Library , International Organization For Standardization , United Kingdom National Healthcare System , Nature Medicine , National Healthcare System , Image Credit , United Kingdom Government , International Organization , Medicine Service , National Genomic Test , Sample Handling Guidance , Illumina Truseq Polymerase Chain Reaction , High Throughput Sequencin , Illumina North Star ,

Study probes cancer's interconnections

The most comprehensive analysis of gene dependencies in cancer cells to date has identified 370 “highly enriched” drug targets in defined molecular backgrounds. This latest iteration of the Cancer Dependency Map, published in Cancer Cell, Jan. 11, 2024, builds on an earlier version published in 2019, which was based on 324 cell lines. ....

Cancer Dependency Map , Cancer Cell , Wellcome Sanger Institute , Bioworld Science , Gene Dependencies ,

Novel blood test shows promise in detecting early-stage cancers with high accuracy

Researchers develop a novel plasma proteome-based test for early detection of multiple cancers, achieving high accuracy in identifying low-abundance protein biomarkers. ....

Neha Mathur , Artemisdiana Shutterstock , Sophia Coveney , Neha Mathurjan , Blood Test , Ucleic Acid ,