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Scientists Develop Model That Simulates Breast Cancer by Angela Mohan on February 23, 2021 at 12:17 PM Scientists developed new xenograft model that simulates breast cancer. The team, led by EPFL researcher George Sflomos, at the laboratory of Professor Cathrin Brisken grafted two ILC-derived metastatic breast cancer cell lines and freshly resected ILC tumors from patients directly into the milk ducts of mice which are immune deficient. The study is published in EMBO Molecular Medicine. Invasive lobular carcinoma (ILC) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It covers 10-15% of all breast cancer cases, has a high risk of late recurrence, unique metastatic sites, high sensitivity to hormones, unpredictable responses to therapies, unique histopathology, distinctive biology, and resists chemotherapy. ....
Xenograft model for invasive lobular carcinoma simulates tumor with high accuracy news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
Credit: George Sflomos (EPFL) Invasive lobular carcinoma (ILC) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It covers 10-15% of all breast cancer cases, has a high risk of late recurrence, unique metastatic sites, high sensitivity to hormones, unpredictable responses to therapies, unique histopathology, distinctive biology, and resists chemotherapy. More than 90% of ILC tumors also contain estrogen receptors, meaning that they can receive hormone signals from the body e.g. estradiol, that can spur their growth and metastasis. Despite all this, ILC is relatively understudied compared to other breast cancers, and as a result, there have been very few models developed to study it. The reason is the lower incidence of ILC in general, but also because ILC tumors don t lend themselves to growth in culture or in mice, which is key to developing models. ....