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Better choice of contraceptives can prevent breast cancer


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IMAGE: Fluorescence stereo micrograph of a mouse mammary gland intraductally injected with normal human breast epithelial cells. Credit: Marie Shamseddin (EPFL).
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Credit: EPFL
Hormonal contraceptives, e.g. the pill, the patch, and the vaginal ring, contain synthetic hormones that prevent pregnancy by either stopping ovulation, changing the cervical mucus to stop sperm from passing through the cervix and finding an egg, or changing the womb s lining to prevent a fertilized egg from being implanted in it.
Despite their widespread use, hormonal contraceptives are known to increase the risk of breast cancer, which is the most common cause of cancer-related death among women worldwide, and also topped the list of most commonly diagnosed cancers in 2020. ....

Stitelsen Stefan Paulssons Cancerfond , Paulssons Stiftelse , School Of Life Sciences , Foundation Cancera Stiftelsen , Swiss National Science Foundation , University Hospital Of Lausanne , International Cancer Prevention Institute , Swiss Cancer League , Professor Cathrin Brisken , Life Sciences , National Science Foundation , Cancer League , Cancera Stiftelsen , Stefan Paulssons Cancerfond , Learning Initiative , Medicine Health , Breast Cancer , பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , சுவிஸ் தேசிய அறிவியல் அடித்தளம் , சர்வதேச புற்றுநோய் ப்ரெவெந்ஶந் நிறுவனம் , சுவிஸ் புற்றுநோய் லீக் , வாழ்க்கை அறிவியல் , தேசிய அறிவியல் அடித்தளம் , புற்றுநோய் லீக் , கற்றல் முயற்சி ,

Scientists model a peculiar type of breast cancer


Credit: George Sflomos (EPFL)
Invasive lobular carcinoma (ILC) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It covers 10-15% of all breast cancer cases, has a high risk of late recurrence, unique metastatic sites, high sensitivity to hormones, unpredictable responses to therapies, unique histopathology, distinctive biology, and resists chemotherapy. More than 90% of ILC tumors also contain estrogen receptors, meaning that they can receive hormone signals from the body e.g. estradiol, that can spur their growth and metastasis.
Despite all this, ILC is relatively understudied compared to other breast cancers, and as a result, there have been very few models developed to study it. The reason is the lower incidence of ILC in general, but also because ILC tumors don t lend themselves to growth in culture or in mice, which is key to developing models. ....

George Sflomos , Lausanne University Hospital , International Cancer Prevention Institute , Professor Cathrin Brisken , University Hospital , Cancer Prevention Institute , Cell Biology , Molecular Biology , Breast Cancer , Biomedical Environmental Chemical Engineering , சர்வதேச புற்றுநோய் ப்ரெவெந்ஶந் நிறுவனம் , பல்கலைக்கழகம் மருத்துவமனை , புற்றுநோய் ப்ரெவெந்ஶந் நிறுவனம் , செல் உயிரியல் , மூலக்கூறு உயிரியல் , மார்பக புற்றுநோய் , உயிர் மருத்துவ சுற்றுச்சூழல் இரசாயன பொறியியல் , உயிரி தொழில்நுட்பவியல் ,