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Frontiers | DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors

Low socioeconomic status (SES) and living in a disadvantaged neighborhood are associated with poor cardiovascular health. Multiple lines of evidence have linked DNA methylation to both cardiovascular risk factors and social disadvantage indicators. However, limited research has investigated the role of DNA methylation in mediating the associations of individual- and neighborhood-level disadvantage with multiple cardiovascular risk factors in large, multi-ethnic, population-based cohorts. We examined whether disadvantage at the individual level (childhood and adult SES) and neighborhood level (summary neighborhood SES as assessed by Census data and social environment as assessed by perceptions of aesthetic quality, safety, and social cohesion) were associated with 11 cardiovascular risk factors including measures of obesity, diabetes, lipids, and hypertension in 1154 participants from the Multi-Ethnic Study of Atherosclerosis (MESA). For significant associations, we conducted epigenome- ....

New York , United States , United Kingdom , Nat Genet , Biochim Biophys Acta , Herttualas Epigenetics , Mitchellc Epigenetics , Johns Hopkins , J Clin Nutr , National Health , Curr Environ Health Rep , Columbia University Medical Center , Lancet Public Health , University Of Michigan , Public Health , University Of Washington , Association Between Individual , University Of Minnesota , Epidemiol Community Health , Blood Institute , Nutrition Examination , National Heart , Data Coordinating Center , Elosuar Association , Wake Forest University Health Sciences , American Community ,