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Preclinical research reveals that new IgM antibodies administered intranasally to fight COVID-19 more potent than commonly used ones

A nasal therapy, built upon on the application of a new engineered IgM antibody therapy for COVID-19, was more effective than commonly used IgG antibodies at neutralizing the COVID-19 virus in animal models, according to research recently published by The University of Texas Health Science Center at Houston (UTHealth), The University of Texas Medical Branch at Galveston (UTMB Health), the University of Houston, and IGM Biosciences, Inc. ....

South Africa , University Of Houston , United States , University Of Texas , South African , Stephenf Carroll , Vineetd Menachery , Xinli Liu , Sujit Biswas , Ningyan Zhang , Junquan Liu , Paulr Hinton , Elizabethj Haanes , Brucea Keyt , Chui Deng , Yang Liu , Xuping Xie , Zhiqiang Ku , Pei Yong Shi , Antonioe Muruato , Kevinb Carlin , Jing Zou , Deepal Pandya , Wei Xiong , Sachi Rahman , Fred Schwarzer ,

Inhaled vaccine induces fast, strong immune response in mice and non-human primates


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Researchers demonstrate in a proof-of-concept study that a phage-based inhalation delivery system for vaccines generates potent antibody responses in mice and non-human primates, without causing lung damage. The findings suggest that a safe and effective lung delivery system could one day be used for vaccines and therapeutics against respiratory diseases. The results appear December 10 in the journal
Med.
This translational strategy potentially enables more effective delivery of therapeutics or vaccines while reducing the chance of toxic side effects, says co-senior study author Wadih Arap of Rutgers Cancer Institute of New Jersey. In ongoing research, we hope that this work will play a crucial role in the development of targeted vaccines and treatments to block the spread of respiratory infectious diseases, possibly for the current COVID-19 pandemic, especially in the setting of underserved populations. ....

United States , Renata Pasqualini , Cancer Center Support , Gillson Longenbaugh Foundation , Rutgers Cancer Institute Of New Jersey , University Of New Mexico Comprehensive Cancer Center , Wadih Arap , Rutgers Cancer Institute , Cancer Center Support Grants , Cancer Center , New Mexico Comprehensive Cancer Center , New Jersey , Phage Display Based Pulmonary Vaccination , Cell Press , ஒன்றுபட்டது மாநிலங்களில் , ரெனாட்டா பாஸ்குவாலீநீ , புற்றுநோய் மையம் ஆதரவு , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் ஆஃப் புதியது ஜெர்சி , பல்கலைக்கழகம் ஆஃப் புதியது மெக்ஸிகோ விரிவான புற்றுநோய் மையம் , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் , புற்றுநோய் மையம் ஆதரவு மானியங்கள் , புற்றுநோய் மையம் , புதியது மெக்ஸிகோ விரிவான புற்றுநோய் மையம் , புதியது ஜெர்சி , ஃபேஜ் காட்சி அடிப்படையிலானது நுரையீரல் தடுப்பூசி , செல் ப்ரெஸ் ,