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Researchers Develop Faster and More Efficient Way To Study Muscle Diseases

To study muscle diseases, scientists rely on the mouse as a model organism. Researchers at the University of Basel have now developed a new method that is not only faster and more efficient than conventional ones but also greatly reduces the number of experimental animals needed for studying the function of genes in muscle fibers. ....

Louise Delmotte Getty , University Of Basel , Nature Communications , Getty Images , Sustainable Alternatives , Animal Experiments That Went , Muscle Fibers , Crispr Cas9 , As9 Protein , Guide Rna ,

A CRISPR on-off switch for genes controls expression without altering DNA


April 12, 2021 A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in
Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression.
The classic CRISPR-Cas9 system led to an explosion in gene editing studies since it was first developed almost a decade ago. It became quickly popular thanks to its ease of use compared to previous gene editing methods.
CRISPR-Cas9 uses guide RNA to chaperone the Cas9 nuclease to a particular site in the DNA and create a double-strand break. By adding a specially designed short sequence of DNA, scientists can introduce permanent genetic changes to the cell. This oligonucleotide is used as a template by the cell when repairing the double-strand break, incorporating the sequence into the cell s genome. However, this approach can cause unintended genetic changes. ....

United States , San Francisco , Luke Gilbert , Jonathan Weissman , University Of California , Jennifer Cook Chrysos Whitehead Institute For Biomedical Research , Massachusetts Institute Of Technology , Massachusetts Institute , Whitehead Institute , Crispr Cas9 , Gene Editing Tools , Guide Rna , Epigenetic Changes , Gene Silencing , Transcriptional Repressor Proteins , Transcriptional Activator Domains , Fusion Proteins , Cas9 Proteins , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , லூக் கில்பர்ட் , ஜொனாதன் வெயிஸ்மேன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , மாசசூசெட்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , மாசசூசெட்ஸ் நிறுவனம் , வைட்ஹெட் நிறுவனம் ,