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Newly identified antibody can be targeted by HIV vaccines


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DURHAM, N.C. - A newly identified group of antibodies that binds to a coating of sugars on the outer shell of HIV is effective in neutralizing the virus and points to a novel vaccine approach that could also potentially be used against SARS-CoV-2 and fungal pathogens, researchers at the Duke Human Vaccine Institute report.
In a study appearing online May 20 in the journal
Cell, the researchers describe an immune cell found in both monkeys and humans that produces a unique type of anti-glycan antibody. This newly described antibody has the ability to attach to the outer layer of HIV at a patch of glycans the chain-like structures of sugars that are on the surfaces of cells, including the outer shells of viruses. ....

Alberto Bartesaghi , Richard Laga , Kartik Manne , Matthews Lee , Sophie Gobeil , S Munir Alam , Josephr Francica , Wilton Williams , Megan Kopp , R Ryan Meyerhoff , Garnett Kelsoe , Marioj Borgnia , Gregoryd Sempowski , Kevin Wiehe , Katayoun Mansouri , Mattia Bonsignori , Guillaume Stewart Jones , Bhavna Hora , Andrew Foulger , Robertj Parks , M Anthony Moody , Celiac Labranche , Allenl Hsu , Barton Haynes , Madison Berry , Margaret Deyton ,