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Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease
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Massive Fragment Screen Points Way to New SARS-CoV-2 Inhibitors

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This news release, originally issued by Diamond Light Source, describes a template for how to develop directly-acting antivirals that would combat COVID-19. The study focused on a specific part of the Nsp3 gene that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. Researchers from the University of California used the Highly Automated Macromolecular Crystallography (AMX) and the Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines at the National Synchrotron Light Source II (NSLS-II) to characterize the molecular structure of proteins involved in this mechanism. The beamlines ultrasmall yet powerful x-rays and rapid sample mounting automation enabled the researchers to collect hundreds of high-resolution datasets per eight-hour shift. NSLS-II is a U.S. Department of Energy (DOE) Office of Science User Facility at DOE’s Brookhaven National Laboratory that offers a comprehensive suite of life science research capabilities ....

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Mutant Gene-Targeted Immunotherapy Approach Developed

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This news release, issued by Johns Hopkins Medicine, describes a novel targeted immunotherapy approach. This new approach employs bispecific antibodies to treat cancer by eliciting a Tcell response against mutated p53. The researchers used the Highly Automated Macromolecular Crystallography (AMX) and Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines to characterize the molecular structure of the proteins. AMX and FMX are beamlines at the National Synchrotron Light Source II (NSLS-II) a U.S. Department of Energy (DOE) Office of Science User Facility at Brookhaven National Laboratory. NSLS-II offers a comprehensive suite of life science research capabilities. Johns Hopkins media contacts: Amy Mone, 410-614-2915, amone@jhmi.edu, or Valerie Mehl, 410-614-2916, mehlva@jhmi.edu. Brookhaven Lab media contacts: Cara Laasch, 631-344-8458, laasch@bnl.gov or Peter Genzer, 631-344-3174, genzer@bnl.gov. ....

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