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congratulations. reporter: but first came motherhood, raising five children before she switched careers. never would i have thought that some day i would go from homemaker to house speaker. reporter: as speaker, pelosi worked with four suspects, often going toe to toe with donald trump. the power of the speaker is awesome. awesome. reporter: president biden today calling her the most consequential speaker of the house in our history. because of nancy pelosi, the lives of millions and millions of americans are better, even in districts represented by republicans who voted against her bills and too often vilified her. pelosi s colleagues cheering as she listed her accomplishments. transformative health care reform with president barack obama. reporter: even newt gingrich in the past year saying you could argue she s been the stronge est speaker in history. pelosi s announcement comes nearly three weeks after her husband was viciously attacked in their san francisco home. ....
hey there, i m victor blackwell. welcome to cnn newsroom. and i m alisyn camerota we begin with end of an era on capitol hill. a short time ago house speaker nancy pelosi said she s stepping down from leadership. now republicans have won control of the house. never would i have thought that some day i d go from homemaker to house speaker. [ applause ] in fact, i never and we great confidence in our caucus, i will not seek re-election to democratic leadership in the next congress. so maybe it s come for a new generation to lead the democratic caucus that i so deeply respect. this closes an important chapter in pelosi s trail blazing congressional career. she s the first and only woman to be house speaker. ....