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Research Reveals Early Cellular Origins of Lung Adenocarcinoma

Research Reveals Early Cellular Origins of Lung Adenocarcinoma
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Texas , United-states , Linghua-wang , National-cancer-institute , University-of-texas-md-anderson-cancer-center , Research-institute-of-texas , Cancer-systems-biology-consortium , Human-tumor-atlas-network , Johnson , Cancer-center , Humam-kadara , Translational-molecular-pathology

Study unravels the earliest cellular genesis of lung adenocarcinoma

Study unravels the earliest cellular genesis of lung adenocarcinoma
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Texas , United-states , Linghua-wang , University-of-texas-md-anderson-cancer-center , Cancer-center , Humam-kadara , Translational-molecular-pathology , Genomic-medicine ,

Research Reveals Origin of Lung Adenocarcinoma Cells

Research Reveals Origin of Lung Adenocarcinoma Cells
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Texas , United-states , Houston , Linghua-wang , Johnson , Research-institute-of-texas , University-of-texas-md-anderson-cancer-center , Cancer-systems-biology-consortium , Human-tumor-atlas-network , National-cancer-institute , Cancer-center , Humam-kadara

New lung cell atlas unveils pathways to lung adenocarcinoma development

Researchers at The University of Texas MD Anderson Cancer Center built a new atlas of lung cells, uncovering new cellular pathways and precursors in the development of lung adenocarcinoma, the most common type of lung cancer.

Texas , United-states , Linghua-wang , Research-institute-of-texas , University-of-texas-md-anderson-cancer-center , National-cancer-institute , Johnson , Cancer-systems-biology-consortium , Human-tumor-atlas-network , Manderson-cancer , Cancer-center , Humam-kadara

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Through extensive single-cell analysis, researchers at The University of Texas MD Anderson Cancer Center have created a spatial map of tumor-infiltrating B cells and plasma cells in early-stage lung cancers, highlighting previously unappreciated roles these immune cells play in tumor development and treatment outcomes.

Texas , United-states , Guangchun-han , Linghua-wang , Ansam-sinjab , Dapeng-hao , Emily-henderson , University-of-texas-md-anderson-cancer-center , Cancer-center , Cancer-discovery , Humam-kadara , Translational-molecular-pathology

MD Anderson research highlights for June 15, 2022

MD Anderson research highlights for June 15, 2022
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Texas , United-states , Houston , B-leticia-rodriguez , Qing-deng , Samrat-kundu , Jiexin-zhang , Robert-bast , Sonjam-woermann , Linghua-wang , Zhen-lu , Joseph-ludwig

AACR 2022 Special Edition

AACR 2022 Special Edition
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United-states , Texas , American , Mabelg-perez-oquendo , Joshua-gray , James-allison , Stephen-mok , Don-gibbons , John-heymach , Guangchun-han , Yu-qian , Linghua-wang

Single-cell map of early stage lung cancer and normal lung sheds light on tumor development, new therapeutic targets


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Single-cell map of early stage lung cancer and normal lung sheds light on tumor development, new therapeutic targets
Researchers at The University of Texas MD Anderson Cancer Center have developed a first-of-its-kind spatial atlas of early-stage lung cancer and surrounding normal lung tissue at single-cell resolution, providing a valuable resource for studying tumor development and identifying new therapeutic targets. The study was published today in Cancer Discovery, a journal of the American Association for Cancer Research.
The findings reveal a heterogeneous lung cancer ecosystem, with extensive interactions between cancer cells and the surrounding microenvironment that regulate early cancer development. By studying the crosstalk between the tumor and surrounding immune cells, researchers identified and validated CD24, an immune checkpoint protein, as a new immunotherapy target for lung cancer treatment.

United-states , Texas , University-of-texas , American , Guangchun-han , Linghua-wang , Ansam-sinjab , American-association-for-cancer-research , National-cancer-institute , University-of-texas-md-anderson-cancer-center , National-institutes-of-health , Research-institute-of-texas