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Low-Risk TAVR at 2 Years: Thrombosis Concerns Creep In


P=0.046)
The TAVR group had had more deaths and strokes between 1 and 2 years compared with the SAVR group, according to the PARTNER 3 investigators led by Martin Leon, MD, of Columbia University Irving Medical Center in New York City. Their report was published in the March 9 issue of the
Clearly, ongoing assessment of clinical and echocardiographic findings is needed in younger and low-risk patients and planned follow-up in PARTNER 3 will continue through at least 10 years, Leon and colleagues wrote.
The convergence in death and stroke came as no surprise to cardiac surgeon Joseph Bavaria, MD, of the Hospital of the University of Pennsylvania in Philadelphia, who participated in the trial. ....

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No Increased VTE Risk With Hormone Therapy During Gender Surgery


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Transgender patients undergoing gender-affirming surgery were not at significant risk for perioperative venous thromboembolism (VTE) whether or not hormone therapy was stopped before surgery, researchers reported.
In a retrospective study that included 407 transgender patients undergoing vaginoplasty, no VTE events occurred in those who continued hormone therapy through surgery, said John Pang, MD, of the Mount Sinai Center for Transgender Medicine and Surgery in New York City, and colleagues.
Reporting online in the
Journal of Clinical Endocrinology and Metabolism, the team said the only VTE event in the study occurred in the group that stopped hormone therapy prior to surgery. ....

New York , United States , Mount Sinai Center , John Pang , Transgender Medicine , New York City , Clinical Endocrinology , Medpage Today , Unable To Concentrate , Hypercoagulability State , Mental Disorder , Mental Health Problem , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஏற்ற சினை மையம் , ஜான் வேதனை , திருநங்கைகள் மருந்து , புதியது யார்க் நகரம் , மருத்துவ உட்சுரப்பியல் , மன கோளாறு , மன ஆரோக்கியம் ப்ராப்லம் ,

What Caused Stroke in Patient Already 'Recovered' From COVID-19?


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A 48-year-old man presents to a medical center in New York City after suddenly developing numbness in his upper left arm, along with weakness, and impairment of positional sensation. He says that for the past 8 hours, he has had severe headaches on the right side of his skull in the back, for which he took ibuprofen. He is right-handed and a nonsmoker.
He notes that he had been diagnosed with SARS-CoV-2 infection about a month earlier, when he went to the same medical center after feeling generally unwell, with fever, low-back pain, and right-sided headache.
At that time, clinicians confirmed COVID-19 via PCR testing. He reports that his symptoms lasted for 12 days, during which he remained quarantined at home, and on day 17, he returned to work. ....

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Staying Safe in Lupus: Monitor Hydroxychloroquine Levels


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Monitoring blood levels of hydroxychloroquine (HCQ) among patients with systemic lupus erythematosus (SLE) could help preserve the anti-thrombotic effects of the drug without increasing the risk for retinal toxicity, researchers reported.
Rates of thrombosis declined by 13% for every increase of 200 ng/mL in overall mean blood levels of HCQ, for a rate ratio of 0.87 (95% CI 0.76-1,
P=0.0559) after adjustment for age, ethnicity, hypertension, lupus anticoagulant, and levels of C3 complement. Significant reductions also were seen specifically for the most recent blood level measurement, with a rate ratio of 0.87 (95% CI 0.78-0.98,
P=0.0249), said Michelle Petri, MD, and colleagues from Johns Hopkins University School of Medicine in Baltimore. ....

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