Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials
Author summary Why was this study done? ➢ Clinicians and researchers depend on the peer-reviewed literature for accurate assessments of drug efficacy and safety, but this depends on whether the outcomes of all trials—negative, as well as positive—are reported transparently. ➢ In an earlier study, using Food and Drug Administration (FDA) review documents as a gold standard, we found that many negative trials had been misreported in the published literature as having positive outcomes or had simply not been published. ➢ Since then, reporting bias has been the s...
Source: plos.org