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The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid lipoxygenase 15b humanized the product pattern and an inverse mutagenesis strategy murinized the specificity of the human enzyme. As the mechanistic basis for these functional differences, an inverse substrate binding at the active site of the enzymes has been suggested, but experimental proof for this hypothesis is still pending. Here we expressed wildtype mouse and human arachid...

UK is a world leader in online safety tech, with a quarter of all firms based here

Visual threat intelligence technology now integrated into OpenText Magellan Risk Guard to aid corporate risk management and compliance London | April 26, 2022 . Image Analyzer Extends Technology Partnership with OpenText | EFE Comunica | Agencia EFE

You don’t have to work at GCHQ to know that one of Gloucestershire’s worst kept secrets is the incredible depth of talent in its cyber sector – and SoGlos has teamed up with BPE to champion some the individuals...

This is not something we should be prolonging by instituting new restrictions on our freedoms of expression, speech and thought. It is vital to stand your ground and fight peacefully for freedom now, before it’s too late.