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UC San Diego Experts Push Biomedicine Forward with Virtual Reality

If you were looking for a poster child for the strength of UC San Diego’s entrepreneurial ecosystem, the company Nanome would be a strong contender.Founded by Steven McCloskey ’15, Keita Funakawa ’16, Edgardo Leija ’14 and Samuel Hessenauer ’16 in 20 ....

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Novartis to invest $300mn in European biotherapeutics

Novartis to invest $300mn in European biotherapeutics
europeanpharmaceuticalreview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from europeanpharmaceuticalreview.com Daily Mail and Mail on Sunday newspapers.

Jonathan Novak , Reto Fischer , Institutes For Biomedical Research , Technical Research Division , Global Drug Development , Biologics Center , Head Of Technical Research Division , Biomedical Research , Global Head ,

Pharma Looks to Inflammasome Inhibitors as All-Around Therapies

Heart failure, gout, COVID-19, melanoma
Completed Phase 1 and Phase 1b in patients with heart failure and Phase 2a in patients with acute gout flares. A Phase 2 trial for people with moderate COVID-19 symptoms is ongoing, and the company is planning a Phase 2 trial in late-stage melanoma, along with an approved immunotherapy.
Drugging the inflammasome
For years after the inflammasome’s initial discovery, the search for drugs that target it yielded no promising leads, Cooper says. “Big pharma all went and screened their libraries of drugs and said, can we find an inhibitor? But no one could.”
Several years ago, that began to change. Luke O’Neill, an immunologist at Trinity College Dublin, was one of the people searching for an NLRP3 inhibitor, with colleagues at his company Opsona. He knew that a scientist named Chris Gabel had been working at Pfizer in the late 1990s on a molecule called CRID3, which appeared to block IL-1β production. O’Neill was int ....

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