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Achieving optimal advanced process control in bioproduction

Achieving optimal advanced process control in bioproduction
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Transcenta Continues to Push the Boundary of Cell Culture Productivity by Achieving > 6 g/L per Day Volumetric Productivity in Continuous Perfusion Platform


Transcenta Continues to Push the Boundary of Cell Culture Productivity by Achieving > 6 g/L PER Day Volumetric Productivity in Continuous Perfusion Platform
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SUZHOU and HANGZHOU, China, March 16, 2021 /PRNewswire/ Transcenta, a global biotherapeutics company with fully-integrated capabilities in discovery, development and manufacturing of antibody-based therapeutics, today announced a major breakthrough in its continuous perfusion cell culture platform by achieving volumetric productivity of > 6 g/L per day while maintaining process and product quality attributes in a state of control for a 4-week culture. This productivity improvement represents a 15-fold increase in drug substance output per year when compared to same cell line in conventional fed-batch process (6 g/L over 14 days). At such high productivity, one 100L or 1,000L single use bioreactor can produce approximately 130 kg or 1.3 metric tons of tota ....

United States , Prnewswire Transcenta , Chris Hwang , Clinical Development Centers , Transcenta Holding , Merck Kga , Merck Kgaa , Product Development Center , Translational Research Center , Chief Technology Officer , Integrated Continuous Bioprocessing , Darmstadt Germany , Manufacturing Facility , External Partnering Center , Transcenta Holding Limited , ஒன்றுபட்டது மாநிலங்களில் , கிறிஸ் ஹ்வ்யாஂக் , மருத்துவ வளர்ச்சி மையங்கள் , மெர்க் க்க , ப்ராடக்ட் வளர்ச்சி மையம் , மொழிபெயர்ப்பு ஆராய்ச்சி மையம் , தலைமை தொழில்நுட்பம் அதிகாரி , டர்ம்ஸ்டட்ட் ஜெர்மனி , உற்பத்தி வசதி , வெளிப்புறம் கூட்டாளர் மையம் ,