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CD19-targeted CAR T cells in refractory antisynthetase syndrome

Idiopathic inflammatory myopathies are a group of rare, immune-mediated diseases that
primarily affect the skeletal muscle but can also involve other organs such as the
lungs, skin, and joints.1 Antisynthetase syndrome comprises a major cluster of such
diseases and is characterised by the development of adaptive immune responses against
various tRNA synthetases, including those for histidine (forming anti-Jo-1 antibodies),
tyrosine (anti-PL7), alanine (anti-PL12), glycine (anti-EJ), isoleucine (anti-OJ),
asparagine (anti-KS), phenylalanine (anti-Zo), and threonine (anti-HA). ....

Deutsche Forschungsgemeinschaft , International Myositis Assessment , Clinical Studies Group , Collaborative Research Center , Elsevier Ltd , Englj Med , Peuropean League Against Rheumatism ,