PIONEER trial: favipiravir to treat moderate COVID-19
As the COVID-19 pandemic claimed lives across the globe, several randomised clinical trials were conducted to evaluate the safety and efficacy of investigational and repurposed therapeutics for the treatment of COVID-19. As a result, a number of new antivirals are now licensed to treat COVID-19, such as nirmatrelvir–ritonavir (Paxlovid), molnupiravir, and remdesivir.1–3 Favipiravir is an RNA-dependant RNA polymerase inhibitor with activity against a range of RNA viruses. The agent is licensed in Japan to treat influenza virus and has been studied and subsequently used to treat SARS-CoV-2 i...