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Glitch in genome architecture may cause B-cell malignancies


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NEW YORK, NY (Feb. 1, 2021) Errors in the way chromosomes are packed into antibody-producing B cells appear to play a role in the development of B cell-related blood cancers, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons.
The findings could lead to new biomarkers for predicting the onset of these cancers and to a new class of cancer therapies that prevent or correct harmful changes in genome architecture.
The study was published online Feb. 1 in the journal
Nature Genetics.
Antibodies are made by immune cells called B cells through a series of carefully controlled chromosome rearrangements and good mutations that allow the cell to make a wide array of different antibodies. Although these changes are essential for generating the vast diversity of antibodies, there is a risk that bad mutations will occur and lead to B cell-derived cancers, says study leader Uttiya Basu, PhD, professor of ....

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