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Aberrant Genome Architectural Organization in Antibody Producing Cells May Cause Cancer Source: Nanoclustering/Science Photo Library/Getty Images February 4, 2021 Share Aberrant packaging of chromosomes in the nuclei of B lymphocytes may play a role in the development of B cell-related blood cancers, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons. New biomarkers for the early diagnosis of a variety of cancers and a new class of cancer therapies that prevent or correct harmful changes in genome architecture, may be developed based on these novel findings. Nature Genetics. Numerous rapid, “good” mutations including large chromosomal rearrangements occur through a series of carefully orchestrated genetic changes and result in the synthesis of an array of high-affinity antibodies in B lymphocytes that specifically bind and neutralize the multitudes of foreign elements (antigens) that enter the ....
E-Mail NEW YORK, NY (Feb. 1, 2021) Errors in the way chromosomes are packed into antibody-producing B cells appear to play a role in the development of B cell-related blood cancers, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons. The findings could lead to new biomarkers for predicting the onset of these cancers and to a new class of cancer therapies that prevent or correct harmful changes in genome architecture. The study was published online Feb. 1 in the journal Nature Genetics. Antibodies are made by immune cells called B cells through a series of carefully controlled chromosome rearrangements and good mutations that allow the cell to make a wide array of different antibodies. Although these changes are essential for generating the vast diversity of antibodies, there is a risk that bad mutations will occur and lead to B cell-derived cancers, says study leader Uttiya Basu, PhD, professor of ....