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Previously Unknown Weak Spot in Prostate Cancer Discovered

A previously undiscovered weakness in prostate cancer cells might pave the way for novel treatment strategies for other types of cancer. Globally, prostate cancer stands as the most prevalent non-skin cancer among men. Based on global approximations, one out of every six men is predicted to develop ....

University Of Connecticut , United States , Stefan Wuchty , Sushant Kumar , Yu Chen , Mark Gerstein , Jean Philippep Theurillat , Marka Rubin , Mark Rubin , Joanna Triscott , Muriel Jaquet , Declan Clarke , Ellen Qian , Georgen Thalmann , Salvatore Piscuoglio , Howardr Soule , Rahuln Kanadia , Kyled Drake , Marco Bolis , Rahul Kanadia , Anke Augspach , Institute For Systems Genomics , Department Of Physiology , Us Prostate Cancer Foundation , Neurobiology Department , Bern Center ,

Researchers reveal the internal signals cells use to maintain energy

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IMAGE: Lipid kinases produce an active messenger that coordinates communications between peroxisomes and mitochondria two organelles intimately involved in making and using fuel to support cellular growth.
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Credit: CI Photos
LA JOLLA, CALIF. - May 12, 2021 - Scientists at Sanford Burnham Prebys Medical Discovery Institute have taken a deep dive into a previously overlooked family of proteins and discovered that they are essential to maintaining the energy that cells need to grow and survive. The proteins, known as lipid kinases, produce messengers that help balance cellular metabolism and promote overall health. The findings, published in Developmental Cell, provide further support to pursue lipid kinases as promising therapeutic targets for diseases that demand excess energy, such as cancer. ....

New York , United States , La Jolla , San Francisco , Gurpreetk Arora , Brooke Emerling , Christof Fellmann , Christian Metallo , Ryanm Loughran , Chantal Pauli , Marka Rubin , Rachelj Lew , Joanna Triscott , Ravi Kumar , Matthias Reist , Lavinia Palamiuc , Sanford Burnham Prebys , Archna Ravi , University Of Bern , Chantal Pauli At University Hospital , University Of Zurich , Developmental Cell , Molecular Biology , Cancer Program , Vivian Tieu , Gladstone Institutes ,