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Fluoxetine, a common antidepressant, inhibits the SARS-CoV-2 coronavirus in cell cultures and in preparations from human lung tissue. This was demonstrated by researchers at Julius-Maximilians-Universität (JMU) Würzburg in the summer of 2020. However, the mechanism of this inhibition was utterly unclear, so the teams continued their research.
E-Mail IMAGE: with one of the newly developed inhibitors in the active centre. The individual domains of the protein are shown in different colours, the inhibitor in pink. view more Credit: © V. Namasivayam/Pharmazeutisches Institut/Uni Bonn A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials...
Scientists map direct interactions between SARS-CoV-2 RNA and human host cells Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urgent tasks is to gain a detailed understanding of the molecular interactions between the virus and the cells it infects. It must also be clarified, whether these interactions favour the multiplication of the v...
Date Time Corona: How virus interacts with cells Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. 18 host proteins play an important role during SARS-CoV-2 infection – two of them are particularly interesting. They could open up new ways to treat infections with SARS-CoV-2 and other RNA viruses. Graphics: SCIGRAPHIX / S. Westermann SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urg...
E-Mail IMAGE: 18 host proteins play an important role during SARS-CoV-2 infection - two of them are particularly interesting. They could open up new ways to treat infections with SARS-CoV-2 and other... view more Credit: SCIGRAPHIX / S. Westermann SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urgent tasks is to gain a detailed understanding of the molecular interactions between the virus and the cells it infects. It must also be clarified, whether these interactions favour the multiplication of the virus or - on the...