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A new drug candidate can shrink kidney cysts

A new drug candidate can shrink kidney cysts
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

Denise-andrade , Sallys-liu , Bogdan-fedeles , Betsyp-leitch , Stefan-somlo , Sakunchai-khumsubdee , Sorin-fedeles , Robert-croy , John-essigmann , Jake-campolo , Research-scientist-nina-gubina , National-institute-of-environmental-health-sciences

Cancer drug holds promise for shrinking polycystic kidney cysts

Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease, can lead to kidney enlargement and eventual loss of function.

Bogdan-fedeles , Sakunchai-khumsubdee , Robert-croy , Stefan-somlo , Betsyp-leitch , Sorin-fedeles , Jake-campolo , John-essigmann , Sallys-liu , Denise-andrade , Yale-university-school-of-medicine , National-institute-of-environmental-health-sciences

A new drug candidate can shrink kidney cysts

A compound originally developed as a cancer treatment may hold promise for treating polycystic kidney disease (ADPKD), which affects more than half a million Americans and can lead to kidney enlargement and loss of function.

Jake-campolo , Stefan-somlo , Robert-croy , Betsyp-leitch , Denise-andrade , Sallys-liu , Sakunchai-khumsubdee , Sorin-fedeles , Bogdan-fedeles , John-essigmann , Research-scientist-nina-gubina , Environmental-health-sciences

Promising drug shrinks kidney cysts.

ADPKD, the prevalent form of polycystic kidney disease, causes kidney enlargement, often leading to function loss.

Robert-croy , Betsyp-leitch , John-essigmann , Stefan-somlo , Bogdan-fedeles , Sallys-liu , Denise-andrade , Sakunchai-khumsubdee , Jake-campolo , Sorin-fedeles , Yale-university-school-of-medicine , Polycystic-kidney-disease-outcomes-consortium

Promising drug shrinks kidney cysts.

ADPKD, the prevalent form of polycystic kidney disease, causes kidney enlargement, often leading to function loss.

Robert-croy , Betsyp-leitch , John-essigmann , Sallys-liu , Bogdan-fedeles , Stefan-somlo , Sakunchai-khumsubdee , Jake-campolo , Denise-andrade , Sorin-fedeles , Yale-university-school-of-medicine , Polycystic-kidney-disease-outcomes-consortium

Gerald Wogan, professor emeritus of biological engineering, chemistry, and toxicology, dies at 91

Gerald Wogan, professor emeritus of biological engineering, chemistry, and toxicology, dies at 91
mit.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from mit.edu Daily Mail and Mail on Sunday newspapers.

Altoona , Pennsylvania , United-states , Chulabhorn , Nakhon-si-thammarat , Thailand , Juniata-college , Hampshire , Illinois , Bangkok , Krung-thep-mahanakhon , University-of-illinois

Study: One enzyme dictates cells' response to a probable carcinogen

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CAMBRIDGE, MA -- In the past few years, several medications have been found to be contaminated with NDMA, a probable carcinogen. This chemical, which has also been found at Superfund sites and in some cases has spread to drinking water supplies, causes DNA damage that can lead to cancer.
MIT researchers have now discovered a mechanism that helps explain whether this damage will lead to cancer in mice: The key is the way cellular DNA repair systems respond. The team found that too little activity of one enzyme necessary for DNA repair leads to much higher cancer rates, while too much activity can produce tissue damage, especially in the liver, which can be fatal.

Massachusetts , United-states , Cambridge , Cambridgeshire , United-kingdom , Stephen-dertinger , Dushan-wadduwage , Dorothea-torous , Ilana-nazari , Jennifer-kay , Ishwar-kohale , Bevin-engelward

Study: One enzyme dictates cells' response to a probable carcinogen | MIT News | Massachusetts Institute of Technology

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Image: MIT News, with DNA images from iStockphoto
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In the past few years, several medications have been found to be contaminated with NDMA, a probable carcinogen. This chemical, which has also been found at Superfund sites and in some cases has spread to drinking water supplies, causes DNA damage that can lead to cancer.
MIT researchers have now discovered a mechanism that helps explain whether this damage will lead to cancer in mice: The key is the way cellular DNA repair systems respond. The team found that too little activity of one enzyme necessary for DNA repair leads to much higher cancer rates, while too much activity can produce tissue damage, especially in the liver, which can be fatal.

Massachusetts , United-states , Harvard-university , Stephen-dertinger , Dushan-wadduwage , Dorothea-torous , Ilana-nazari , Jennifer-kay , Ishwar-kohale , Bevin-engelward , John-essigmann , Leona-samson

Designing in a pandemic to fight a pandemic

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Image: Sean Clarke
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Last fall, seniors in the MIT Department of Biological Engineering (BE) took on the most relevant of all possible design challenges — the Covid-19 pandemic. The capstone design class in the Course 20 major, class 20.380 (Biological Engineering Design) has a different theme every semester, and in September there was little doubt about this fall’s topic — Addressing the Pandemic with BE. “We weren't sure how students would respond. Would they be exhausted by Covid? Instead, students leapt at the chance to apply their skills to such an immediate problem,” says Professor Angela Koehler, a member of the teaching team.

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