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"Christchurch Mutation" – How Good Can Overpower Evil in Alzheimer's Disease Genetics

New research sheds light on protective mechanisms of the “Christchurch mutation.” Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most co

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Patient-Inspired Antibody Therapy Lessens Alzheimer's Tau Tangles

Patient-Inspired Antibody Therapy Lessens Alzheimer's Tau Tangles
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Antibody therapy inspired by patient case reduces tau tangles in a preclinical model of Alzheimer's disease

Antibody therapy inspired by patient case reduces tau tangles in a preclinical model of Alzheimer's disease
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He defied Alzheimer's for two decades. Scientists want to know how

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Early Alzheimer's: Rare genetic mutation may delay onset of disease

Researchers say a rare genetic mutation may help delay the onset on early Alzheimer's in people who carry a gene that puts them at high risk of developing the disease

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He defied Alzheimer's for two decades. Scientists want to know how

The patient had been born with a particularly sinister gene mutation that should have doomed him to dementia before his 50th birthday.

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Naturally existing genetic resilience found in patient predisposed to Alzheimer's

In a patient with delayed onset of the Alzheimer's disease despite having a genetic predisposition to its early-onset, researchers have identified a genetic mutation that could have helped him remain cognitively intact until his late 60s.

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