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Novel immunotherapy boosts long-term stroke recovery in mice


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IMAGE: These images show how regulatory T cells (Treg cells) boost the ability of microglia cells to promote the regeneration of the brain s white matter (right), compared to a sample not.
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Credit: Xiaoming Hu/University of Pittsburgh
PITTSBURGH, May 19, 2021 - Specialized immune cells that accumulate in the brain in the days and weeks after a stroke promote neural functions in mice, pointing to a potential immunotherapy that may boost recovery after the acute injury is over, University of Pittsburgh School of Medicine neurologists found.
The study, published today in the journal
Immunity, demonstrated that a population of specialized immune cells, called regulatory T (Treg) cells, serve as tissue repair engineers to promote functional recovery after stroke. Boosting Treg cells using an antibody complex treatment, originally designed as a therapy after transplantation and for diabetes, improved behavioral and cognitive function ....

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