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Deep learning-based splice-AI can help predict the onset of Alzheimer's disease

Deep learning-based splice-AI can help predict the onset of Alzheimer s disease
Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.
This research outcome was published in
PNAS, a world-renowned academic journal.
Prediction of Alzheimer s Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening
Alternative splicing variant regulates gene expression and influences diverse phenotypes. Especially, genetic variants arising due to RNA splicing are frequently found in individuals having neurodevelopmental disorders. ....

South Korea , Suh Pann Ghill , Jae Yeol Joo , Emily Henderson , Korea Brain Research Institute , Brain Research Institute , President Suh Pann Ghill , Deep Learning Based Approach , Fourth Industrial Revolution , Alzheimer 39s Disease , Deep Learning , Amino Acid , Corona Virus , Gene Expression , High Throughput Screening , Phospholipase C , தெற்கு கொரியா , எமிலி ஹென்டர்சன் , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , மூளை ஆராய்ச்சி நிறுவனம் , ஆழமான கற்றல் அடிப்படையிலானது அணுகுமுறை , நான்காவது தொழில்துறை புரட்சி , ஆழமான கற்றல் , அமினோ அமிலம் , கொரோனா வைரஸ் , கீந் வெளிப்பாடு ,

Predicts the onset of Alzheimer's Disease (AD) using deep learning-based Splice-AI

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IMAGE: High-throughput total RNA-seq profile for PLCγ1 and PLCβ subfamily gene expression in the cortex
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Credit: KBRI
Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.
This research outcome was published in
PNAS, a world-renowned academic journal.
(Title) Prediction of Alzheimer s Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening
Alternative splicing variant regulates gene expression and influences diverse phenotypes. Especially, genetic variants arising due to RNA splicing are frequently found in individuals having neurodevelopmental disorders. ....

South Korea , Suh Pann Ghill , Jae Yeol Joo , National Research Foundation Of Korea , Korea Brain Research Institute , President Suh Pann Ghill , Deep Learning Based Approach , Fourth Industrial Revolution , National Research Foundation , Cell Biology , Health Care , Algorithms Models , Medicine Health , தெற்கு கொரியா , தேசிய ஆராய்ச்சி அடித்தளம் ஆஃப் கொரியா , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , ஆழமான கற்றல் அடிப்படையிலானது அணுகுமுறை , நான்காவது தொழில்துறை புரட்சி , தேசிய ஆராய்ச்சி அடித்தளம் , செல் உயிரியல் , ஆரோக்கியம் பராமரிப்பு , மருந்து ஆரோக்கியம் ,

Uncovers the molecular mechanism behind synapse loss in Alzheimer's disease

Credit: KOREA BRAIN RESEARCH INSTITUTE
Korea Brain Research Institute (KBRI, Pann-Ghill Suh (President)) announced that Dr. Kea Joo Lee and Dr. You-Na Jang of the Neural Circuits Research Group have identified the mechanism causing synaptic loss in Alzheimer s disease as the aberrant expression of RAPGEF2, a synaptic protein.
- The results were published on January 2021, in the online Early View of
Neuropathology and Applied Neurobiology.
(Title) RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer s disease
Alzheimer s disease (AD) accounts for about 75% of dementia cases and is the most common type of degenerative brain disease. AD is a devastating because disease progression can cause memory loss, mood disorder, slurred speech, confusion, and impaired movement. ....

South Korea , Kea Joo Lee , Pann Ghill Suh , National Research Foundation Of Korea , Korea Brain Research Institute , Neural Circuits Research Group , You Na Jang , Early View , National Research Foundation , Medicine Health , Alzheimers Disease , தெற்கு கொரியா , கீ ஜூ லீ , தேசிய ஆராய்ச்சி அடித்தளம் ஆஃப் கொரியா , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , நரம்பியல் சுற்றுகள் ஆராய்ச்சி குழு , நீங்கள் நா ஜங் , ஆரம்ப பார்வை , தேசிய ஆராய்ச்சி அடித்தளம் , மருந்து ஆரோக்கியம் , அல்சைமர் நோய் ,

Astrocytes eat connections to maintain plasticity in adult brains

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IMAGE: A 3-D animated image showing our synapse phagocytosis reporter in mouse hippocampus. Presynapses in green, astrocytes in white, and microglia in blue. Phagocytosed presynapses by glia were shown in red..
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Credit: KAIST
Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections the ones that are repeatedly introduced, such as how to avoid danger are nurtured and reinforced, while connections deemed unnecessary are pruned away. Adult brains undergo similar pruning, but it was unclear how or why synapses in the adult brain get eliminated.
Now, a team of researchers based in Korea has found the mechanism underlying plasticity and, potentially, neurological disorders in adult brains. They published their findings on December 23 in ....

South Korea , Hyoeun Lee , Joon Hyuk Lee , Ji Young Mun , Seulgi Noh , Suk Chung , Young Lee , Department Of Brain , Department Of Biological Sciences , Cognitive Sciences , Samsung Science Technology Foundation , National Research Foundation Of Korea , Research Group For Neurovascular Unit , Daegu Gyeongbuk Institute Of Science , Korea Brain Research Institute , Research Group For Neural Circuit , Korea Advanced Institute Of Science , Won Suk Chung , Biological Sciences , Professor Chung , Hyungju Park , Samsung Science , Technology Foundation , National Research Foundation , Korea Advanced Institute , Ji Young Kim ,