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Leading investigators in diabetes, pancreas and islet biology, and computational biology have received $12.5 million in two five-year awards from the National Institutes of Health to create the world's first, integrated knowledgebase of human-derived tissue- and cellular-level pancreatic information to support innovative, collaborative and reproducible research.
Genetic Tools Detect Culprit for Type 1 Diabetes by Angela Mohan on May 21, 2021 at 10:28 AM Nature. Type 1 diabetes is am autoimmune disease with loss of insulin-producing pancreatic beta cells. It is less common than type 2 diabetes, but its prevalence is growing. Currently, there is no cure, only disease management. The U.S. Centers for Disease Control and Prevention projects 5 million Americans will have type 1 diabetes by 2050. Numerous genome-wide association studies (GWAS) have been conducted in recent years in which researchers compare whole genomes of persons with...
By mapping its genetic underpinnings, researchers have identified a predictive causal role for specific cell types in type 1 diabetes.
Genomic analysis reveals cellular cause of type 1 diabetes 1 Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes. By mapping its genetic underpinnings, researchers at University of California, San Diego, US, have identified a predictive causal role for specific cell types in type 1 diabetes. According to the researchers, type 1 diabetes is characterised by the impairment and loss of insulin-producing pancreatic beta cells and subsequent hyperglycemia. The mechanisms of type 1 diabetes, including how autoimmunity is trig...