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Proteins play crucial role in muscle growth

Proteins play crucial role in muscle growth
When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells.
The same thing happens when an injured muscle starts to heal. At the same time, however, the muscle stem cells must produce further stem cells - i.e., renew themselves - as their supply would otherwise be depleted very quickly. This requires that the cells involved in muscle growth communicate with each other.
Muscle growth is regulated by the Notch signaling pathway
Two years ago, a team of researchers led by Professor Carmen Birchmeier, head of the Developmental Biology/Signal Transduction Lab at the Berlin-based Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), showed that the development of stem cells into muscle cells is regulated with the help of two proteins, Hes1 and MyoD, which are produced in the progenitor cells in an ....

Max Delbr , Jana Wolf , Carmen Birchmeier , Ines Lahmann , Yao Zhang , Katharina Baum , Emily Henderson , Nature Communications , Developmental Biology Signal Transduction Lab , Helmholtz Association , Professor Carmen Birchmeier , Signal Transduction Lab , Berlin Based Max Delbr , Molecular Medicine , Professor Jana Wolf , Developmental Biology , Notch Signaling , Progenitor Cells , Signaling Pathway , Stem Cells , ஜன ஓநாய் , கார்மென் பிர்ச்மியர் , யாவ் ஜாங் , காதரின பாம் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் ,

In Vivo Probes for Detecting Inflammation Markers in Humans and Animals

In Vivo Probes for Detecting Inflammation Markers in Humans and Animals
Thought LeadersProf. Parastoo HashemiSenior Lecturer in Bioengineering, Imperial London College
Associate Professor of Chemistry, University of South Carolina
In this interview, News-Medical Life Sciences talks to Parry Hashemi about the research on in vivo probes for detecting inflammation markers in humans and animals that she will present at Pittcon.
What are some traditional methods for detecting inflammation markers in humans and animals?
Traditionally, a blood or plasma sample will be taken. There are certain proteins that indicate an inflammation; for example, pro-inflammatory cytokines. If the levels of these are raised that corresponds to inflammation. ....

Parry Hashemi , Department Of Chemistry , University Of South Carolina , Life Sciences , Sponsored Content , Parastoo Hashemiassistant Professor , News Medical Life Sciences , Hashemi Interview , In Vivo , Health Care , Immune Response , Immune System , பாரி ஹஷேமி , துறை ஆஃப் வேதியியல் , பல்கலைக்கழகம் ஆஃப் தெற்கு கரோலினா , வாழ்க்கை அறிவியல் , ஆதரவளிக்கப்பட்ட உள்ளடக்கம் , செய்தி மருத்துவ வாழ்க்கை அறிவியல் , ஹஷேமி நேர்காணல் , இல் விவோ , ஆரோக்கியம் பராமரிப்பு , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி அமைப்பு ,

SHREK proteins mediate broad spectrum antiviral host immunity, including against SARS-CoV-2

A new preprint posted to the bioRxiv server demonstrates that similar mucins and mucin-like proteins cannot only suppress HIV-1 infectivity via blockage of viral attachment to the host cells but can block infection by multiple enveloped viruses. ....

Liji Thomas , Rigidly Extended Killer , Sars Cov 2 , Coronavirus Disease Covid 19 , Hiv 1 , Progenitor Cells ,

Remyelinating drug shows potential to improve vision in patients with MS

Remyelinating drug shows potential to improve vision in patients with MS
A team led by a biomedical scientist at the University of California, Riverside, reports a drug an estrogen receptor ligand called indazole chloride (IndCl) has the potential to improve vision in patients with multiple sclerosis, or MS.
The study, performed on mice induced with a model of MS and the first to investigate IndCl s effect on the pathology and function of the complete afferent visual pathway, is published in
Brain Pathology. The afferent visual pathway includes the eyes, optic nerve, and all brain structures responsible for receiving, transmitting, and processing visual information. ....

United States , Riverside School , Seema Tiwari Woodruff , Johna Katzenellenbogen , Emily Henderson , University Of California , University Of Illinois At Urbana Champaign , Uc Riverside School Of Medicine , Multiple Sclerosis , Immune System , Mouse Model , Optic Neuritis , ஒன்றுபட்டது மாநிலங்களில் , ஆற்றங்கரை பள்ளி , சீமா திவாரி வூட்ரஃப் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் இல் ஊர்பன சாம்பியன் , அக் ஆற்றங்கரை பள்ளி ஆஃப் மருந்து , பல ஸ்க்லரோசிஸ் , நோய் எதிர்ப்பு சக்தி அமைப்பு , சுட்டி மாதிரி ,

Scientists discover new treatment target for osteoarthritis-like knee cartilage degeneration

Scientists discover new treatment target for osteoarthritis-like knee cartilage degeneration
There is currently no cure for osteoarthritis, but a group of scientists believe they ve discovered a method through which a simple knee injection could potentially stop the disease s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that treating mice with surgery-inducedknee cartilage degeneration through the same pathway via the state of the art of nanomedicine could dramatically reduce the cartilage degeneration and knee pain. These findings were published in ....

United States , Zhiliang Cheng , Jaimo Ahn , Emily Henderson , University Of Pennsylvania , Perelman School Of Medicine , University Of Michigan , Science Translational , Associate Professor , Orthopaedic Surgery , Perelman School , Penn Engineering , Penn Medicine , Growth Factor , Knee Pain , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , பெரல்மேன் பள்ளி ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் , அறிவியல் மொழிபெயர்ப்பு , இணை ப்ரொஃபெஸர் , எலும்பியல் அறுவை சிகிச்சை , பெரல்மேன் பள்ளி , பென் பொறியியல் , பென் மருந்து ,