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20 Awesome Events & Special Offers in Guangzhou

Enjoy a nice week with events from our editor s picks! ....

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Six-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism | BMC Medicine

Accumulating evidence has suggested an oncogenic effect of diurnal disruption on cancer progression. To test whether targeting circadian rhythm by dietary strategy suppressed lung cancer progression, we adopted 6-h time-restricted feeding (TRF) paradigm to elucidate whether and how TRF impacts lung cancer progression. This study used multiple lung cancer cell lines, two xenograft mouse models, and a chemical-treated mouse lung cancer model. Stable TIM-knockdown and TIM-overexpressing A549 cells were constructed. Cancer behaviors in vitro were determined by colony formation, EdU proliferation, wound healing, transwell migration, flow cytometer, and CCK8 assays. Immunofluorescence, pathology examinations, and targeted metabolomics were also used in tumor cells and tissues. mCherry-GFP-LC3 plasmid was used to detect autophagic flux. We found for the first time that compared to normal ad libitum feeding, 6-h TRF inhibited lung cancer progression and reprogrammed the rhythms of metabolites ....

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Haitong reins in Hong Kong unit after US$840 million blowout

Haitong Securities plans to revamp its Hong Kong investment bank, halting an expansion after the firm posted unprecedented losses last year. The… ....

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福建：坚守岗位尽职责 冲锋在前勇担当 - 民生

编者按：在防控疫情第一线，我省广大党员干部冲锋在前、勇于担当，涌现出一批坚守岗位、履职尽责的先进典型。240名县乡党员领导干部下沉一级兼任临时党组织第一书记或村（社区）党组织第一书记，1957名党员干部下沉到疫情防控一线，1.5万多名党员冲锋在疫情防控工作一线，牢牢构筑起抗疫的“红色长城”。 ....

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