Promising First Results With DNA Editing to Lower LDL
The first-in-human HEART-1 trial of in vivo DNA editing called VERVE-101, shows reductions in LDL and PCSK9 protein in patients with familial hypercholesterolemia.
Source: medscape.com
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New Study Links Sphingolipids With Palmitic Acid to Increased Risk of Sudden Cardiac Death
Plasma ceramides and sphingomyelins with palmitic acid were linked to a 34% and 37% increased risk of sudden cardiac death (SCD) per higher SD of log sphingolipid levels, respectively.
Source: ajmc.com
Novel Agent Seladelpar Improves Markers of PBC Activity
For 1 in 4 patients with primary biliary cholangitis (PBC) who received the investigational PPAR-delta agonist, alkaline phosphatase levels normalized.
Source: medscape.com
Study Takes Fine-Grained Look at MACE Risk With GCs in RA
'Up to half of RA patients in the United States use long-term glucocorticoids despite previous work suggesting they increase MACE in a dose-dependent way.'
Source: medscape.com
Pharmacist-Based Strategy Places More Patients on Statins
In two studies run in parallel, testing different strategies, automatic referral to a pharmacist was superior to EHR alerts for increasing statin prescriptions for at-risk patients.
Source: medscape.com