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Researchers have identified significant and specific variations in the microbial universe of the small intestine in overweight or obese adults compared with normal-weight peers.
Study finds slightly higher risk in children at 10 years, but experts say this shouldn't change current supplementation recommendations.
The experimental siRNA agent led to prolonged Lp(a) reduction of more than 90%, extended data from the phase 1 trial show, supporting the move to phases 2 and 3 trials.
In patients with severe hypertriglyceridemia who are at risk for acute pancreatitis, the drug brought about triglyceride reductions of more than 50% in the phase 2 SHASTA-2 study.
A drug targeting mRNA essential for APO C-III production provided a 50% reduction in triglycerides in BRIDGE-TIMI 73a, the largest ever observed in a controlled trial.