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Lerodalcibep, a third-generation PCSK9 inhibitor, reduced LDL by more than 50% vs placebo in patients with or at a high risk for CVD in the phase 3 LIBerate-HR trial.
In patients with STEMI and multivessel disease, FFR-guided complete nonculprit revascularization did not reduce events vs culprit lesion-only PCI in the FULL-REVASC trial.
The PROACT trial assessing enalapril in patients with cancer undergoing chemotherapy showed this approach did not affect cardiac function or the rate of cardiac injury.