Novel PCSK9 Inhibitor Reduced LDL by 50%
Lerodalcibep, a third-generation PCSK9 inhibitor, reduced LDL by more than 50% vs placebo in patients with or at a high risk for CVD in the phase 3 LIBerate-HR trial.
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Lerodalcibep, a third-generation PCSK9 inhibitor, reduced LDL by more than 50% vs placebo in patients with or at a high risk for CVD in the phase 3 LIBerate-HR trial.
The novel agent has shown no immunogenicity issues thus far and might be a promising new PCSK9 inhibitor option.
90% of high-risk patients on lerodalcibep achieved guideline-recommended cholesterol targets
Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or "bad" cholesterol, levels by more than half on average, compared with a placebo.
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