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LIBerate-HR: Lerodalcibep Lowers LDL More Sharply Than Placebo Over 1 Year

The novel agent has shown no immunogenicity issues thus far and might be a promising new PCSK9 inhibitor option.

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Increased Lp(a) Ups CV Risk Regardless of hs-CRP Level

This suggests a broader swath of patients could be included in Lp(a)-lowering studies and potentially benefit from these agents.

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STS Survey Identifies Stark Gender Disparities in Compensation

Leaders say that transparency and identification of the problem is the first step toward fixing it.

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Erectile Dysfunction Drugs Don't Mix Well With Nitrates After MI, PCI

The findings, from a nationwide Swedish study, bolster the contraindication to using these drugs in combination.

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Big Reductions in ASCVD Events With Bempedoic Acid in Primary Prevention

While there can be a debate over the effect size, or the reduction in mortality, experts say the drug fills an unmet need.

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Obicetrapib Effective When Added to Statins and Ezetimibe: ROSE2

The CETP inhibitor’s development checked another box, with investigators showing it works when added to existing therapies.

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Ezetimibe Plus Moderate-Dose Statins May Aid Compliance in the Elderly

This subanalysis of the RACING trial suggests older patients with ASCVD may do better on this regimen than on high-dose statins.

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Don't Just Prescribe a Statin—Measure and Control LDL, Say NLA, ASPC

A new statement argues for the return of a performance metric that sees physicians track the efficacy of their LDL-C treatments.

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Cardiac Biomarkers May Help Refine HF Risk Stratification, Progression

The findings from the ARIC cohort are suggestive of “a graded set of risks” within Stage B heart failure, says James L. Januzzi Jr.

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Sustained LDL-Cholesterol Reductions With Inclisiran: ORION-3

LDL-C stayed down for 4 years and so did PCSK9 levels, but the real test for inclisiran will be the ongoing CV outcomes studies.

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