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Conclusions
In the present study, CNPs were successfully prepared; they had a relatively small and uniform particle size, and stable physical and chemical properties. CNPs can increase the Cur solubility, and β-CD block the drugs in mesoporous silicon channels and graft cRGD as targeting groups recognized by academia. And combined with EPR effect, we can achieve better tumor targeting. Moreover, CNP carriers demonstrated a low hemolysis rate and ideal cell compatibility, and they did not cause any obvious irritative damage to the intact skin. CNPs played an anti-cancer role by inducing apoptosis of S phase and G2/M phase cells. In vitro and in vivo experiments also showed that CNPs had good tumor-targeting ability and anti-tumor activity. In conclusion, CNPs have an ideal biosafety and therapeutic effect for recurrent BC. ....

United States , New Zealand , Eteläuomen Läi , Dnc Dpc , Aladdin Reagent Co Ltd Shanghai , Sinopharm Chemical Reagent Co Ltd Shanghai , Greenbird Inc , Zhengzhou University , Meryer Chemical Technology Co Ltd Shanghai , Stem Cell Bank , Experimental Animal Center , Aldrich China Co Ltd Shanghai , Meloney Biotechnology Co Ltd Dalian , National Institutes Of Health , Chinese Academy Of Sciences , Asia Reagent Co Ltd Chengdu , Ethical Committee Of Zhengzhou University , Anhui Muweixing Technology Co Ltd Hefei , Modified Eagle Medium , Chinese Academy , Ethical Committee , National Institutes , Zetasizer Nano , Loading Content , Encapsulation Efficiency , Skin Irritation Tests ,