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Novel Curcumin Derivative-Decorated Ultralong-Circulating Paclitaxel Nanoparticles: A Novel Delivery System with Superior Anticancer Efficacy and Safety

Conclusions In the present study, CNPs were successfully prepared; they had a relatively small and uniform particle size, and stable physical and chemical properties. CNPs can increase the Cur solubility, and β-CD block the drugs in mesoporous silicon channels and graft cRGD as targeting groups recognized by academia. And combined with EPR effect, we can achieve better tumor targeting. Moreover, CNP carriers demonstrated a low hemolysis rate and ideal cell compatibility, and they did not cause any obvious irritative damage to the intact skin. CNPs played an anti-cancer role by inducing apopt...

E) PSN1:4:4, ( F) PSN1:8:8. The direction of the arrows represents the position of the hydrogen bond between PTS and EE-PVA. We also investigated the hydro-binding of PTS and nanocarriers using 1H-NMR spectra (Figure 4B–F). We observed several characteristic protons in the PTS 1H-NMR spectra, such as aromatic protons in the regions of δ6.3–7.5 ppm, methyl protons at δ3.8, and hydroxyl protons at δ9.6 (Figure 4B). In addition, Figure 4 shows that the integrated intensity at δ9.6 ppm of PTS was observed in PSN with excipient ratios of 1:2:2 (Figure 4D) and 1:4:4 (Figure 4E); however, ...