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Very helpful in categorizing certain conditions. Giving people some sense, based on which categories. When it failed that is the underlying. Having most people understand that i mean, theres value in it, but really asking why, whats going on. I think the more we learn, the more we will come to understand that its not specific neurotransmitters. As they can play a role in this disorder or that disorder, but to really understand how neural circuits really become sensitized, how those narrow circuits, those groups get laid down. We think that is what is key. The reality is, the reason why this has been so hard, i mean, just because once those neural circuits get strengthened, how long do they lack, they respond, so they can last a lifetime. But, the good news is we can lay down new neural circuits and i think i mean, i think increasingly those who provide care understand that the goal is to try to lay down those new neural circuits. Thank you very much. [applause]. [applause]. We do have ....