In The Lancet, Manfred Accrombessi and colleagues1 report the results of a rigorous cluster-randomised, controlled, superiority trial in Benin, encompassing 54 030 households and 216 289 people, which confirms that the addition of the pyrrole insecticide chlorfenapyr to long-lasting insecticidal nets (LLINs), as a second active ingredient to back up the pyrethroids we have relied upon so heavily for so long, can have invaluable effects on malaria transmission and disease burden. A total of 115 323 LLINs were distributed to 54 030 households and the primary outcome of mean malaria case ...