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[Full text] The Combination Therapy of Fluorouracil and Oxaliplatin Suppress the P
15 and so on. For example, SOCS3 was downregulated in triple-negative breast cancer, overexpression of SOCS3 result in a less aggressive oncogenic phenotype. 13 Also, Wang et al have shown that SOCS3 upregulation promoted cell apoptosis and suppressed proliferation of pancreatic cancer SW1990 cells. 16 In our article, our goal was to investigate the impact of the combination of FU and OXA on the expression of PD-L1 and malignant biological behavior of CRC HCT116 cells via miR-183-5p/SOCS3 axis. Materials and Methods Tissue Samples Tissue specimens were obtained from CRC patients who were admi...
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