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MIT neuroscientists find two distinct cell populations in the striatum are affected differently by Huntington’s disease. They believe neurodegeneration of one of these populations leads to motor impairments, while damage to the other population, located in a structure called the striosome, may account for the mood disorders that are often see in the early stages of the disease.

Neurons in the striatum, a part of the brain affected by Huntington's disease, are among the most severely affected

Neurons in the striatum, a part of the brain affected by Huntington disease, are among the most severely affected. The degeneration of these neurons contribut

MIT research shows that in people carrying the APOE4 risk variant, a key brain cell type mismanages cholesterol needed to insulate neurons properly — another sign that APOE4 contributes to Alzheimer's disease by disrupting lipids in the brain.

Study in cells and mice suggests that the variant APOE4 affects the all-important insulation around nerve cells