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Silencing of Long Non-Coding RNA HOTAIR Alleviates Epithelial–Mesenchymal Transition in Pancreatic Cancer via the Wnt/β-Catenin Signaling Pathway

6 MiRNAs are critical components of competing endogenous RNA network in cells. 7 Via binding to complementary sites on mRNA 3ʹUTR, miRNAs promote mRNA degradation or inhibit mRNA translation to repress gene expression. 8 Dysregulation of miRNAs results in abnormal expression of target genes and is associated with cancer development. 9 Hundreds of cancer-associated miRNAs have been reported in colorectal cancer. 10,11 For example, miR-193a-3p, which is downregulated in BRAF-mutated colorectal cancers, inhibits colorectal cancer cell proliferation. 12 MiR-4449 is highly expressed in serum from...

Yifan Yu, Wenshan Zuo, Wei Cai, Yong Xu, Weidong Liu, Zexue Zhao Department of Orthopaedics, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an City, Nanjing Province, 223300, People’s Republic of China Correspondence: Wenshan Zuo Department of Orthopaedics, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huaiyin District, Huai’an City, Nanjing Province, 223300, People’s Republic of China Introduction: Lnc712 has been characterized as an oncogenic lncRNA in breast cancer. This study aimed to inv...

1 1Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou City, Guangdong Province 510630, People’s Republic of China; 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, People’s Republic of China Correspondence: Xiangyu Wang Department of Neurosurgery, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province 510630, People’s Republic of China Background: Circular RNA circSKA3 plays an oncogenic role in breast cancer, while its rol...

Background Despite the environmental value of biobased lubricants, they account for less than 2% of global lubricant use due to poor thermo-oxidative stability arising from the presence of unsaturated double bonds. Methyl branched fatty acids (BFAs), particularly those with branching near the acyl-chain mid-point, are a high-performance alternative to existing vegetable oils because of their low melting temperature and full saturation. Results We cloned and characterized two pathways to produce 10-methyl BFAs isolated from actinomycetes and γ-proteobacteria. In the two-step bfa pathway of a...