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Massive Select's Rare, Tiered & Con Exclusive Covers Direct To Stores

Massive Select's Rare, Tiered & Con Exclusive Covers Direct To Stores
bleedingcool.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bleedingcool.com Daily Mail and Mail on Sunday newspapers.

Barcelona , Comunidad-autonoma-de-cataluna , Spain , San-diego , California , United-states , Denver , Colorado , American , Kevin-roditeli , Sean-gordon-murphy , Michael-calero

'People who were around in the 80s can still dance for hours!'

'People who were around in the 80s can still dance for hours!'
leicestermercury.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from leicestermercury.co.uk Daily Mail and Mail on Sunday newspapers.

Bristol , City-of , United-kingdom , Guildford , Surrey , Leicester , Glasgow , Glasgow-city , Edinburgh , Cambridge , Cambridgeshire , Scotland

NEBuilder® HiFi DNA Assembly Cloning Kit from New England Biolabs Inc.

Read independent reviews on NEBuilder® HiFi DNA Assembly Cloning Kit from New England Biolabs Inc. on SelectScience

Assembly-master-mix , Master-mix , Nebuilder-hifi-dna-assembly-cloning-kit , New-england-biolabs-inc- , Cientific , Aboratory , Roduct , Etails , Eviews ,

Reducing variability in protein purification

In this article, Analytik Jena details what technology can be used to make protein purification lessvariable and faster, with the help of liquid-handling equipment.

Coomassie , Ashanti , Ghana , Cybio-feli , Spectrummill-agilent , Ernst-abbe , Louis-castel , Analytik-jena , Cybio-robotiptray , Analytik-jena-usdec , Cybio-tiprack , Carl-zeiss

An Exclusive Evening with José González tickets in St. Paul at The Fitzgerald Theater on Fri, Nov 10, 2023

An Exclusive Evening with José González tickets in St. Paul at The Fitzgerald Theater on Fri, Nov 10, 2023
axs.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from axs.com Daily Mail and Mail on Sunday newspapers.

United-states , Brazil , Sweden , Gothenburg , Vastra-gotalands-lan , American , Brazilian , Ben-stiller , Simon-garfunkel , Svenska-grammofonstudion , Shuggie-otis , John-lennon

Stratification of enterochromaffin cells by single-cell expression analysis

Stratification of enterochromaffin cells by single-cell expression analysis
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Melbourne , Victoria , Australia , Sydney , New-south-wales , Fiji , United-states , Jesus-olvera , Sct-cartpt-trpm , Mechanosensor-piezo , Perkin-elmer , Elsa-molina

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ) repairs mitotic DSBs and thereby maintains genome integrity. In contrast to other DSB repair factors, Polθ function is activated in mitosis upon phosphorylation by Polo-like kinase 1 (PLK1). Phosphorylated Polθ is recruited by a direct interaction with the BRCA1 C-terminal domains of TOPBP1 to mitotic DSBs, where it mediates joining of broken DNA ends. Loss of Polθ leads to defective repair of mitotic DSBs, resulting in a loss of genome integrity. This is further exacerbated in cells that are deficient in homologous recombination, where loss of mitotic DSB repair by Polθ results in cell death. Our results identify mitotic DSB repair as the underlying cause of synthetic lethality between Polθ and homologous recombination. Together, our findings reveal the critical importance of mitotic DSB repair in the maintenance of genome integrity. In mitosis, genome integrity is maintained by DNA polymerase theta-dependent repair of DNA double-strand breaks, which is regulated by Polo-like kinase 1 activity.

Fiji , Phoenix , Arizona , United-states , Hela-gibco , Biotinylated-pol , Orbitrap-exploris , Lipofectamine-rnaimax-thermofisher , Jn-mark-glover , Mai-tai-deepsee , Giemsa-karyomax , Institut-curie

Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity

Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United-states , Seurat-findclusters , Trustain-fc , Miltenyi-biotec , Aurora-cytek-biosciences , Jackson-laboratory , University-of-pittsburgh-or-center , National-institutes-of-health , Anwita-biosciences-inc , University-of-pittsburgh-center , Committee-of-the-university-pittsburgh , School-of-medicine

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Canada , United-states , Kossa , Sachsen , Germany , Toronto , Ontario , Sakura-finetek , Zeiss-axiovert , Qiagen-rneasy , Vicryl-ethicon , National-institutes-of-health

Streamlining assay development with EVIK Lyophilized Master Mix Beads

In this application note, Evik Diagnostics introduces its EVIK Lyophilized Master Mix Reagent Beads, which streamline the development of stable, durable, and reproducible molecular diagnostic assays. These beads reduce the risk of assay failure in sensitivity and stability, save time and costs by eliminating the need for enzyme and excipient selection, and significantly shorten the project timelines for process development, validation, and device assays. By utilizing EVIK qPCR Master Mix Beads,

Application-note , Master-mix , Evik-diagnostics , Master-mix-reagent-beads , Mix-beads , Evik-master , Eads , Eagent , Treamline , Ssay , Olecular-diagnostic