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Female kidneys are known to be more resilient to disease and injury, but males need not despair. A new USC Stem Cell-led study published in Developmental Cell describes not only how sex hormones drive differences in male and female mouse kidneys, but also how lowering testosterone can "feminize" this organ and improve its resilience.
SUNNYVALE, Calif., Jan. 31, 2022 -- NTT Research, Inc., a subsidiary of NTT, and Cornell University today announced that scientists representing their
Molecular Switch Identified That Flips from Self-Renewal to Specialization in the Making of a Kidney April 5, 2021 Share Self-renewal and specialization are two opposing functions in progenitor cells. Scientists resolve the mechanisms behind the opposing developmental actions of beta-catenin, a co-activator of the established molecular Wnt signaling pathway, that paradoxically regulates both self-renewal and specialization of mammalian progenitor cells destined to become kidney cells. The new study led by Andrew McMohan, PhD, chair of the department of stem cell biology and regenerative medic...
E-Mail IMAGE: From left, Andy McMahon, Lisa Rutledge, Helena Bugacov and Alex Guo hold an impromptu lab meeting. view more Credit: Christina Gandolfo Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. In a new study in the journal eLife from Andy McMahon's laboratory in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC, former graduate student Alex Quiyu Guo and a team of scientists ...