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Subgroup Analysis Shows Consistent Benefit for Dostarlimab Plus Chemo in Nonsquamous in NSCLC

Overall response rates were similar across subgroups of patients with nonsquamous non–small cell lung cancer for the combinations of dostarlimab-gxly plus chemotherapy and pembrolizumab plus chemotherapy, and responses numerically favored the dostarlimab-based combination in most subgroups, according to a subgroup analysis of the phase 2 PERLA trial. ....

Ortega Granados , Laura Ortega Granados , European Lung Cancer Congress , University Hospital Of Ja , Lung Cancer , Medical Oncology Unit , University Hospital , Lung Cancer Congress , Nonsquamous Non Small Cell Lung Cancer , Dostarlimab Gxly , 2023 European Lung Cancer Congress , Phase 2 Perla Trial Nct04581824 ,

Cureus | SARS-CoV-2 Antibody Seroprevalence in Patients With Cancer on Systemic Antineoplastic Treatment in the First Wave of the COVID-19 Pandemic in Portugal

At the time of the first wave of the COVID-19 pandemic, patients with cancer were considered to be at high risk of serious illness and had a higher exposure risk since they needed frequent and nondeferrable hospital visits. Serological tests were not routinely used, and seroprevalence in this population was unknown.

A single-center, cross-sectional study was developed to determine the seroprevalence of anti-SARS-CoV-2 antibodies (Abs) in patients with cancer undergoing systemic antineoplastic treatment. One hundred patients were consecutively recruited in a two-week period (6th-20th May 2020), and serum samples were tested for the presence of immunoglobulin M (IgM) and immunoglobulin G (IgG) Abs directed against both spike (S) and nucleocapsid (N) SARS-CoV-2 proteins in two distinct time points (at recruitment and 4-8 weeks later). IgG-positive results were subject to confirmation, in the same serum sample, using two distinct assays.

At the time of the first study visit, ....

United States , Portuguese Health Authority , Portuguese National Health Authority , Hospital Da Luz Lisboa Ethics Committee , Eastern Cooperative Oncology Group , Luz Lisboa Ethics Committee , Medical Oncology Unit , Igg Abs , Cov Igg , Igg Abbott Architect , Abbott Diagnostics , Oncology Unit , Luz Lisboa , Performance Status , Abbott Architect , Day Hospital ,

Antibiotic Link to Rise in Early Onset Colon Cancer?


Antibiotic Link to Rise in Early Onset Colon Cancer?
By Liam Davenport
July 12, 2021 Exposure to antibiotics appears to be associated with the development of colon cancer, particularly in younger people, and could be contributing to the increase in early onset colorectal cancer (CRC) that is being documented, say UK researchers.
The team conducted study using data from primary care in Scotland, which involved almost 8,000 cases of CRC and over 30,000 healthy controls.
The analysis suggests that a history of antibiotic use among individuals younger that 50 appeared to increase the risk of developing colon cancer (but not rectal) by 49%.
To our knowledge, this is the first study to link antibiotic use with the growing risk of early onset colon cancer, a disease which has been increasing at a rate of at least 3% per year over the last two decades, said study presenter Sarah Perrott, a medical student at the University of Aberdeen, Scotland, U.K. ....

United Kingdom , Sarah Perrott , Alberto Sobrero , Leslie Samuel , University Of Aberdeen , World Congress On Gastrointestinal Cancer , Aberdeen Royal , Medical Oncology Unit , Ospedale San Martino , ஒன்றுபட்டது கிஂக்டம் , சாரா பெறிரோத்ட் , லெஸ்லி சாமுவேல் , பல்கலைக்கழகம் ஆஃப் குட்டைநாய் வகை , உலகம் காங்கிரஸ் ஆன் இரைப்பை குடல் புற்றுநோய் , குட்டைநாய் வகை அரச , மருத்துவ புற்றுநோயியல் அலகு ,