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The causal effects of lipoprotein particles, lipids, and other metabolites on blood pressure (BP).

​​Cancer is associated with significant economic impacts. Quantifying the scale of these impacts is challenged by confounding variables that jointly influence both cancer status and economic outcomes such as healthcare costs and quality of life. Moreover, the increasing costs attributed to cancer drug development complicate the cost-effective provision of cancer care.  

Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depression in people of East Asian ancestry. Multiple Mendelian randomisation (MR) methods were used to test the relationship between (a) BMI and (b) waist-hip ratio (WHR) with depression. Firstly, we performed two-sample MR using genetic summary statistics from a recent genome-wide association study (GWAS) of depression (w...

Regular coffee consumption has been in the news for various reasons- the pleasant and the not so pleasant.

The study used genetics to analyze coffee-drinking behavior. It suggests that consuming java in moderation does not increase the risk of miscarriage, stillbirth or premature birth.