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Re: A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study

Re: A drug target for erectile dysfunction to help improve fertility, sexual activity, and wellbeing: mendelian randomisation study
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Dear Editor , Mendelian Randomisation , Erectile Dysfunction , Specific Phosphodiesterase , Annu Rev Pharmacol Toxicol , Mendelian Randomization , Causal Inference Using Genetic Variants ,

Causal effects of lipids, lipoproteins, and other metabolites on blood pressure

The causal effects of lipoprotein particles, lipids, and other metabolites on blood pressure (BP). ....

Mendelian Randomisation , United Kingdom , United Kingdom Biobank , Blood Pressure , Arterial Stiffness , Cardiovascular Disease ,

Using Mendelian Randomisation to model the causal effect of cancer on health economic outcomes and to simulate the cost-effectiveness of anti-cancer interventions

Cancer is associated with significant economic impacts. Quantifying the scale of these impacts is challenged by confounding variables that jointly influence both cancer status and economic outcomes such as healthcare costs and quality of life. Moreover, the increasing costs attributed to cancer drug development complicate the cost-effective provision of cancer care. ....

Padraig Dixon , University Of Oxford , Mendelian Randomisation , United Kingdom Biobank ,

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality | BMC Medicine

Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depression in people of East Asian ancestry. Multiple Mendelian randomisation (MR) methods were used to test the relationship between (a) BMI and (b) waist-hip ratio (WHR) with depression. Firstly, we performed two-sample MR using genetic summary statistics from a recent genome-wide association study (GWAS) of depression (with 15,771 cases and 178,777 controls) in people of East Asian ancestry. We selected 838 single nucleotide polymorphisms (SNPs) correlated with BMI and 263 SNPs correlated with WHR as genetic instrumental variables to estimate the causal effect of BMI and WHR on depression using the inverse-variance weighted (IVW) method. We repeated these analyses stratifying by home location st ....

United Kingdom , Kadoorie Biobank , Mendelian Randomisation , East Asian , East Asia , United States , China Kadoorie Biobank ,

Debate rages on merits, demerits of regular coffee intake

Regular coffee consumption has been in the news for various reasons- the pleasant and the not so pleasant. ....

United States , Takeshi Hashimoto , Jessical Gleason , Ritsumeikan University , University Of Copenhagen , International Association Of Athletics Federations , World Health Organisation , Lund University , International Agency For Research On Cancer , American Academy Of Obstetricians , Working Group , International Agency , South American , Lancet Oncology , Mendelian Randomisation , American Academy , International Association , Athletics Federations , World Athletics , Professor Takeshi Hashimoto , American Journal ,