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Target ALS and Alzheimer's Drug Discovery Foundation Announce Award Recipients for Biomarker Research

/PRNewswire/ Target ALS and the Alzheimer s Drug Discovery Foundation (ADDF) announced today the first four award recipients in a new initiative to identify. ....

City Of , United Kingdom , New York , United States , Ronalds Lauder , Manuel Matamala Universidad , Jessica Robin Winterlight , Vanja Schneider , Dan Doctoroff , Howard Fillit , Bill Gates , Alejandro Bisquertt Zavala Neurognos , Cruz Universidad , Lou Gehrig , Leonarda Lauder , Mercedes Prudencio Mayo , Niranjan Bose , Agustin Iba , Manish Raisinghani , Leonard Petrucelli , Pietro Fratta University College , Pietro Fratta University College London , Magdalini Polymenidou University Of Zurich , Gianluigi Zanusso University Of Verona , Giuseppe Legname Trieste International School For Advanced , Andreas Hermann German Center ,

Target ALS and Alzheimer's Drug Discovery Foundation Announce Award Recipients for Biomarker Research

Innovative Partnership Funds Research into Diagnostic Tools for Alzheimer s Disease, ALS and Other Neurodegenerative DiseasesNEW YORK, Aug. 30, 20. ....

New York , United States , City Of , United Kingdom , Ronalds Lauder , Manuel Matamala Universidad , Jeff Bezos , Jessica Robin Winterlight , Mackenzie Scott , Vanja Schneider , Dan Doctoroff , Howard Fillit , Bill Gates , Alejandro Bisquertt Zavala Neurognos , Cruz Universidad , Lou Gehrig , Leonarda Lauder , Mercedes Prudencio Mayo , Niranjan Bose , Agustin Iba , Manish Raisinghani , Leonard Petrucelli , Association For Frontotemporal Degeneration , Eli Lilly Company , Pietro Fratta University College , Pietro Fratta University College London ,

Sans Nuclear TDP-43, Splicing of An ALS/FTD Gene Goes Awry

25 Apr 2021
In amyotrophic lateral sclerosis and frontotemporal dementia, loss of the RNA-binding protein TDP-43 from the nucleus creates a surge of mis-spliced mRNAs in neurons. So far, only one of these errant transcripts, stathmin-2, has been tied to disease pathology. Now, two preprints uploaded to bioRXiv on April 4 detail another UNC13A. Variants in this gene increase risk for ALS/FTD.
Neurons lacking nuclear TDP-43 mis-splice UNC13A, make less of the protein.
UNC13A risk variants incorporate cryptic exons.
This only occurs in brain and spinal cord tissue harboring TDP-43 deposits.
One paper was penned by researchers led by Pietro Fratta, University College London, and Michael Ward, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland. The second is from the labs of Aaron Gitler, Stanford University, California, and Leonard Petrucelli, Mayo Clinic, Jacksonville, Florida. Both papers report that if TDP-43 binding to UNC13A falters, t ....

Johns Hopkins University , United States , New York , Stanford University , Baylor College Of Medicine , Matthew Keuss , Pietro Fratta , Rosa Ma , Mercedes Prudencio , Sarah Hill , Huda Zoghbi , Philip Wong , Aaron Gitler , Anna Leigh Brown , Yuka Koike , Oscar Wilkins , Leonard Petrucelli , Michael Ward , Chelsea Weidman Burke , University College London , York Genome Center , Mayo Clinic Brain Bank , National Institute Of Neurological Disorders , National Institute , Neurological Disorders , Mayo Clinic ,