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Targeted therapy combination extends survival in BRAF -mutant melanoma

CHICAGO — Adjuvant dabrafenib plus trametinib reduced mortality risk for adults with resected stage III BRAF V600-mutant melanoma, according to final results of the randomized phase 3 COMBI-AD trial. The findings, presented at ASCO Annual Meeting, also reaffirmed 3- and 5-year updates on improved RFS and distant metastasis-free survival for individuals in the study’s treatment arm. ....

United States , Western Australia , Paulb Chapman , Mindy Valcarcel , Byjosh Friedman , Meyer Cancer Center At Weill Cornell Medicine , Melanoma Institute Australia , Meyer Cancer Center , Weill Cornell Medicine , Newyork Presbyterian Hospital ,

Identifying the initial steps in colorectal cancer formation

Identifying the initial steps in colorectal cancer formation
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Anxo Martinez , Hiroto Kinoshita , Jorge Moscat , Maria Diaz Meco , Department Of Pathology , Meyer Cancer Center At Weill Cornell Medicine , Laboratory Medicine At Weill Cornell , Cancer Pathobiology , Laboratory Medicine , Weill Cornell , Weill Cornell Medicine , Meyer Cancer Center , Anxo Martinez Ordo , Edward Meyer Cancer Center ,

Researchers identify the initial steps in colorectal cancer formation

Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results, published on May 29 in Developmental Cell, overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has a chance to become established. ....

Jorge Moscat , Maria Diaz Meco , Hiroto Kinoshita , Anxo Martinez , Moscat Lab , Meyer Cancer Center At Weill Cornell Medicine , Department Of Pathology , Laboratory Medicine At Weill Cornell , Weill Cornell Medicine , Developmental Cell , Cancer Pathobiology , Laboratory Medicine , Weill Cornell , Meyer Cancer Center , Anxo Martinez Ordo , Edward Meyer Cancer Center ,