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Targeted therapy combination extends survival in BRAF -mutant melanoma

CHICAGO — Adjuvant dabrafenib plus trametinib reduced mortality risk for adults with resected stage III BRAF V600-mutant melanoma, according to final results of the randomized phase 3 COMBI-AD trial. The findings, presented at ASCO Annual Meeting, also reaffirmed 3- and 5-year updates on improved RFS and distant metastasis-free survival for individuals in the study’s treatment arm.

United statesWestern australiaPaulb chapmanMindy valcarcelByjosh friedmanMeyer cancer center at weill cornell medicineMelanoma institute australiaMeyer cancer centerWeill cornell medicineNewyork presbyterian hospital

Unveiling Initial Stages of Colorectal Cancer Development

Unveiling Initial Stages of Colorectal Cancer Development
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Anxo martinezHiroto kinoshitaMaria diaz mecoJorge moscatMoscat lab providedDepartment of pathologyMeyer cancer center at weill cornell medicineLaboratory medicine at weill cornellWeill cornell medicineDevelopmental cellCancer pathobiologyLaboratory medicineWeill cornellMeyer cancer centerAnxo martinez ordoEdward meyer cancer center

Identifying the initial steps in colorectal cancer formation

Identifying the initial steps in colorectal cancer formation
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Maria diaz mecoJorge moscatAnxo martinezHiroto kinoshitaDepartment of pathologyLaboratory medicine at weill cornellMoscat lab providedMeyer cancer center at weill cornell medicineWeill cornell medicineDevelopmental cellCancer pathobiologyLaboratory medicineWeill cornellMeyer cancer centerAnxo martinez ordoEdward meyer cancer center

Identifying the initial steps in colorectal cancer formation

Identifying the initial steps in colorectal cancer formation
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Anxo martinezHiroto kinoshitaJorge moscatMaria diaz mecoDepartment of pathologyMeyer cancer center at weill cornell medicineLaboratory medicine at weill cornellCancer pathobiologyLaboratory medicineWeill cornellWeill cornell medicineMeyer cancer centerAnxo martinez ordoEdward meyer cancer center

Researchers identify the initial steps in colorectal cancer formation

Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results, published on May 29 in Developmental Cell, overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has a chance to become established.

Jorge moscatMaria diaz mecoHiroto kinoshitaAnxo martinezMoscat labMeyer cancer center at weill cornell medicineDepartment of pathologyLaboratory medicine at weill cornellWeill cornell medicineDevelopmental cellCancer pathobiologyLaboratory medicineWeill cornellMeyer cancer centerAnxo martinez ordoEdward meyer cancer center