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Targeted therapy combination extends survival in BRAF -mutant melanoma - Vimarsana News

Targeted therapy combination extends survival in BRAF -mutant melanoma

CHICAGO — Adjuvant dabrafenib plus trametinib reduced mortality risk for adults with resected stage III BRAF V600-mutant melanoma, according to final results of the randomized phase 3 COMBI-AD trial. The findings, presented at ASCO Annual Meeting, also reaffirmed 3- and 5-year updates on improved RFS and distant metastasis-free survival for individuals in the study’s treatment arm.

Source: healio.com
Experts Urge Stopping Melanoma Trial Because of Failure and Harm - Vimarsana News

Experts Urge Stopping Melanoma Trial Because of Failure and Harm

New results from a phase 3 trial may shut the door on the addition of PD–1 or PD–ligand 1 inhibitors to the combination of BRAF and MEK inhibitors for the treatment of BRAF V600–mutated melanoma.

Time's Up for Anti-PD-1/L1 Plus Targeted Therapy in BRAF Melanoma - Vimarsana News

Time's Up for Anti-PD-1/L1 Plus Targeted Therapy in BRAF Melanoma

Third trial testing the approach shows no significant PFS improvement